IntraStem is a new intracellular delivery system that overcomes a problem in pluripotent stem cell culture as well as being applicable to many other mammalian cell types. The system, involving GAG-binding enhanced transduction, enables intracellular delivery of proteins, nucleic acids and particles into cells that resist other non-viral strategies. Delivery of proteins that promote cellular pluripotency and differentiation, delivery and expression of mRNA, and high-yield delivery of nano and microparticles have all been exemplified.
IntraStem has been shown to increase intracellular delivery of protein by two-orders of magnitude and is especially effective at delivering these payloads to pluripotent stem cells that proved resistant to conventional cell penetrating peptide strategies.
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